Nasal sprays became over-the-counter drugs in 1975 after initial success as prescription medications. Afrin nasal spray, for example, is an over the counter product containing this oxymetazoline hcl compound. What you may be referring to is a rebound effect that can occur if you use over-the-counter nasal decongestant sprays regularly. Uses … In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Oxymetazoline is generally available as a nasal spray.It binds to α 1 adrenergic receptors and α 2 adrenergic receptors, most notably.One study classified it in the following order: α(2A) > α(1A) ≥ α(2B) > … Prolonged or frequent use and high dose levels of xylometazoline hydrochloride can lead intranasally to burning or dryness of the mucosa as well as to reactive congestion with Rhinitis medicamentosa. After a few days of using this type of nasal spray, your nose may become less responsive to the effects of the medication. Studies show a combination of medicines to counter addiction, and effective rehabilitation programs like our nasal spray addiction treatment center is the proven way to cure patients. This effect may be apparent after as little as 5 days’ treatment and may trigger permanent mucosal damage with crust formation (Rhinitis sicca). However, studies have revealed that misuse and overuse of xylometazoline leads to rebound congestion, hyper-reactivity, tolerance, and histologic changes of nasal mucosa.4, 5,6,7 The objectives of this paper are to assess the optimal dosage of xylometazoline use in adults and children; as well as to determine the duration Classification The active ingredient, Oxymetazoline hydrochloride is classified as a topical decongestant. Excipients with known effect: polyoxyl hydrogenated castor oil (2.750 mg/ml) For the full list of excipients, see section 6.1. Medically reviewed by John Carew, MD Nasal Spray: Too Good To Be Healthy . Various treatments are available to tackle the negative effects of drug overuse and addiction. Afrin Nasal Spray Can Be Effective But Overuse Causes Problems. Oxymetazoline hydrochloride is an agonist at A1 and A2 adrenergic receptors.This compound is primarily found in nasal decongestant products because it causes vasoconstriction of the nasal passage and thus allows proper airflow when nasal congestion occurs. Fact checked by Ashley Hall Can Rhinostat Be Helpful in Treating Rebound Congestion? Most nasal sprays contain Oxymetazoline hydrochloride which was developed from xylometazoline at E. Merck Darmastadt by Fruhstorfer in 1961. My little girl started going to daycare for the first time in her three years of living, and you can guess what happened. Each metered-dose spray delivers 0.14 mg of xylometazoline hydrochloride. The more often a person uses chemicals such as phenylephrine, xylometazoline and oxymetazoline, the worse their chronic symptoms become over time. Summary: High blood pressure is found among people who take Xylometazoline hydrochloride, especially for people who are female, 60+ old. Otrivine Congestion Relief 0.1% Nasal Spray, nasal solution contains 1 mg/ml of xylometazoline hydrochloride. The winter of 2011 was a rough one for me. Medically reviewed by Sanja Jelic, MD The 7 Best Sinus Decongestants of 2021. Long-term effects Drug misuse. Oxymetazoline is a topical decongestant, used in the form of oxymetazoline hydrochloride.It was developed from xylometazoline at E. Merck Darmstadt by Fruhstorfer in 1961. Misuse of xylometazoline drops has been reported among prisoners who falsely reported symptoms of rhinosinusitis and allergic reaction in order to obtain the psychoactive effects of inhaled xylometazoline, described as “stimulation”, “excitation”, and “feelings of strength” [7]. Nasal sprays can relieve a congested nose or throat, but people can develop a dependence with some types. 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